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Antitope and VasGene Therapeutics Announce the Successful Generation of Two Therapeutic Antibodies

Antitope Limited, UK. and VasGene Therapeutics, Inc. Announce the Successful Generation of Two Therapeutic Antibodies

July 2006 Antitope Ltd., a leader in the generation of therapeutic human antibodies, and VasGene Therapeutics, Inc., a leader in the development of therapeutics based on new discoveries in vascular biology, today announced the completion of a successful collaboration for the generation of two therapeutic antibodies which target proliferative vascular diseases. For the collaboration, Antitope applied its Composite Human Antibody technology to novel targets identified by VasGene, resulting in antibodies that inhibit pathways common to most vascular growth factors that are produced in cancer and vascular diseases such as age related blindness-macular degeneration.

"We are delighted to be working with such an innovative and progressive company as VasGene" said Matthew Baker Ph.D, Chief Executive Officer of Antitope Limited. "Our collaboration with VasGene has demonstrated the success of our Composite Human Antibody technology and we are excited about the prospects for VasGene's therapeutic antibodies."

"Antitope's leadership and scientific staff did an outstanding job and we hope to have many other collaborative projects with their company" said Raymond A. Mirra, Jr., VasGene's Chief Executive Officer.

About Antitope

Antitope Ltd. is a privately-held Cambridge UK-based biotechnology company specializing in immunogenicity testing and the engineering of therapeutic antibodies/proteins with reduced immunogenicity. Antitope's proprietary Composite Human Antibody technology builds upon the previous pioneering work of its founders in the detection and removal of T cell epitopes in antibodies/proteins through humanization and DeImmunisation technologies. Antitope is a privately-held company and has established multiple commercial relationships with leading biotechnology and pharmaceutical companies. For further information on Antitope visit http://www.antitope.co.uk/.

About VasGene

VasGene Therapeutics, Inc. is a privately-held Los Angeles-based clinical-stage biopharmaceutical company dedicated to the development and commercialization of innovative therapeutics based on new understandings in vascular biology. VasGene's cofounders bring a strong track record in vascular biology, discovery of novel targets and therapeutics, developing products that have gained FDA approval including Taxol® and DaunoXome®. VasGene's first clinical-stage product, VeglinTM, targets VEGF (Vascular Endothelial Growth Factor) and has shown responses in a range of solid tumors. For more information on VasGene visit http://www.elusys.com/.